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Theophylline is a drug used in combination with other medications for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Comment. Many people with COPD have mild forms of the disease for which little therapy is needed other than smoking cessation. a. routinely indicated in moderate to very severe COPD b. use limited by narrow therapeutic profile and drug-drug interaction potential c. a potent bronchodilator d. available only in parenteral form 1995 May;107(5 Suppl):206S-209S. Use of theophylline in the treatment of COPD Chest. Theophylline is used to treat lung diseases such as asthma and COPD (bronchitis, emphysema).It must be used regularly to prevent wheezing and shortness of breath. A blood test must be done to monitor your theophylline level to make sure the drug level is … Author J Ramsdell 1 Affiliation 1 University of California at San Diego, USA. Dyspnea is influenced by both physiologic and psychologic factors. doi: 10.1378/chest.107.5_supplement.206s. Breathlessness is common in patients with chronic obstructive pulmonary disease (COPD) and often is the reason that the individual patient seeks medical attention. Treatment. Delivered either orally or intravenously, theophylline acts as a bronchodilator to reduce airway reactivity that leads to wheezing and shortness of breath. It is usually taken by mouth as a pill. Even for more advanced stages of disease, effective therapy is available that can control symptoms, slow progression, reduce your risk of complications and exacerbations, and improve your ability to lead an active life. Theophylline Theophylline is a bronchodilator that is not commonly used for COPD in the U.S. since most people can use inhaled bronchodilators. Theophylline (dimethylxanthine) has been used to treat airway diseases for more than 80 years. Theophylline has no role in treating patients with chronic stable COPD or acute COPD exacerbations. Drugs used to treat COPD The following list of medications are in some way related to, or used in the treatment of this condition. I have had several patients come to me who were taking theophylline and were reluctant to stop, but unless further studies confirm the small decrease in hospitalizations, I will no longer prescribe theophylline for my COPD patients. * Which of the following best describes the role of theophylline in COPD treatment? Used primarily for maintenance treatment of COPD or asthma but is not a preferred agent in either disease; also used in apnea of prematurity not responding to other therapies Aminophylline is converted to theophylline systemically; 1 mg aminophylline = 0.8 mg theophylline Use of theophylline in the treatment of COPD. 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